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BY THE ASSOCIATED PRESS
BISMARCK, N.D. — North Dakota’s Board of Pharmacy has scheduled a Nov. 30 meeting to consider banning more chemicals used in synthetic drugs.
State Attorney General Wayne Stenehjem on Thursday asked the board to use an emergency rule to ban additional substances identified by the state crime lab and other labs across the country.
The meeting will come in the wake of Stenehjem’s orders this week that two so-called head shops — Hemp Horizonz in Minot and Big Willies in Mandan — stop selling synthetic drugs. It also follows a high-profile case in eastern North Dakota and northwestern Minnesota in which nearly a dozen people were criminally charged in what authorities say was a synthetic drug ring that killed two teenagers and sent others to the hospital.
The pharmacy board used an emergency rule two years ago to outlaw several chemicals used in substances that mimic the effects of illegal drugs such as marijuana and LSD, and the state Legislature added more substances during the 2011 session. But state crime lab forensic scientist Charlene Schweitzer told The Bismarck Tribune that new substances not covered by the law showed up within weeks.
“I reached the conclusion that we cannot wait, even three or four months until the session of the (2013) Legislature comes in, because the lives and health of citizens in North Dakota and especially our young people are at stake,” Stenehjem told the pharmacy board Thursday, according to KXMB-TV.
The board agreed to consider an emergency rule Nov. 30 to broaden the state’s synthetic drug ban. If Gov. Jack Dalrymple approves of the process and the board passes the ban, the rules will be filed with the Legislative Council and will go into effect. The board will have to hold a public hearing within 60 days of the filing before making the rules permanent.
After the board first outlawed some of the synthetic drug alternatives in 2010, judges threw out cases of people charged before the emergency rules became permanent, saying the public had not been given enough notice of the changes. Stenehjem said his office will work with the pharmacy board to make sure that doesn’t happen this time.
Assistant Attorney General Edward Erickson said the notice of the Nov. 30 meeting will be posted on the attorney general’s website, the pharmacy board’s website and will be distributed to known sellers of the substances. If the rules are adopted, notice will be filed with the Legislative Council, posted on the attorney general’s and pharmacy board’s websites, and advertised with all of the state’s newspapers.
By Pierre Tristam
One wonders sometimes what our elected officials are smoking. Especially in light of the hysteria over synthetic marijuana and bath salts.
Local governments all over Florida are racing each other to ban those little packets of “incense” sold in convenience stores for $20 or $30 a pop under the name of Spice, Galaxy Gold, Mr. Nice Guy or K-2, among others.
The banning is taking place often in legally suspect ways, as in Palm Coast — where the city council this week will prohibit stores from selling the packets or face a $300-a-day fine, even though the products are legal. Broward County did the same. The Volusia County Council of Governments is urging a similar course. Palm Beach County may be next.
The bans are proliferating with little to no hard evidence that the stuff is anywhere near as dangerous as doomsayers make it sound. Compared to a day’s worth of alcohol poisoning, the long-term effects of smoking or the prevalence of last year’s hysteria of choice — the abuse of prescription painkillers — synthetic pot is an outlier.
A couple of examples: To make his case before the Palm Coast City Council, a sheriff’s deputy flashed a claim during his PowerPoint that synthetic pot is “800 times stronger than marijuana,” and that side effects include “vomiting, agitation, fast heartbeat, elevated blood pressure, seizures, hallucinations, (and) psychotic episodes.” No sources were provided, and no qualifiers to the statements, which council members repeated and local newspapers reprinted.
Actually, those side effects are far milder and their list far shorter than those associated with any common anti-depressant, which are prescribed to children, train conductors and elected officials.
As for the origin of the “800 times stronger” claim, I traced it down to a 1992 Journal of Medicinal Chemistry article that referred to one manufactured chemical compound, HU-210, which had been tested “in various animal species” and found to have “effects 100 to 800 times more potent than THC,” the main compound in marijuana.
The article did not cite effects on humans because it’s never been tested that way. Nor did it specify how much HU-210 must be administered to have such disproportionate effects. HU-210, by the way, is illegal by federal and Florida law.
In Palm Coast, the council did what politicians do when they want to scare people into submitting to new rules: It played the kids card, claiming the ban would protect adolescents. But children are not the problem. Dawn Sollee, an assistant director at the Florida Poison Information Center, says the drugs appeal mostly to people in their mid-20s.
Local governments are getting in the business of bans because it makes them look like they’re doing something at a time when budget cuts and hung-over economies have put them on the defensive.
If synthetic pot is illegal, then it’s a law enforcement matter. It’s not the place of city or county code enforcement officers to police what products are on storeowners’ shelves. President Barack Obama did sign the Synthetic Drug Prevention Act in July, banning numerous chemicals used to make synthetic pot. Gov. Rick Scott did the same a few months earlier.
Still, police raids must prove guilt. It costs a lab $500 and many weeks to determine whether the compounds in seized products are illegal. But local government corner-cutters don’t want to bother with the legalities. They’d rather flex their muscle and intimidate merchants, calculating that shop-owners won’t challenge the tactic.
Local governments are trampling due process to enforce a legal shortcut. In the derelict war on drugs, it’s governments’ latest high. And it’s more disturbing than any pothead’s.
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Researchers at Univ. of California, San Diego Moores Cancer Center are evaluating the safety and tolerability of a synthetic cannabinoid called dexanabinol. Delivered as a weekly intravenous infusion, the drug is being tested in patients with all forms of brain cancer, both primary and metastatic.
“In this Phase I study, we are examining the safety of multiple doses of dexanabinol, extent of penetration into the brain and suitability for future trials,” says Santosh Kesari, principal investigator, and director of neuro-oncology, UC San Diego Moores Cancer Center. “What we hope to determine is the safe and optimal dose of drug in the brain.”
Dexanabinol is a cannabinoid derivative that causes no psychotropic effects. It was tested previously as a neuroprotective in patients with traumatic brain injury. During these trials the drug was found to cross the blood-brain barrier. More recently, researchers at e-Therapeutics plc, who are supporting the current trial, showed that dexanabinol kills cultured cancer cells derived from many tumor types. Additional research in Kesari’s lab demonstrated the drug’s anti-cancer effects in patient-derived brain cancer cell lines.
Dexanabinol’s potential in fighting cancer was identified through a new approach to drug discovery called network pharmacology, a way to analyze the network of proteins underlying a disease process. Network pharmacology enables scientists to seek drugs from among existing compounds, or design new molecules, that act simultaneously on a number of individual proteins to disrupt the cancer-related networks.
Kesari adds that this trial fits well with a broader national effort to re-purpose existing drugs for the treatment of cancer. He asked, “Why not use drugs that are currently available and learn how they can be applied in new effective ways for different indications?”
Dexanabinol is thought to act on proteins including NFĸB, TNFα, COX-2 HAT, FAT and cyclin-dependent kinases. The trial at UCSD Moores Cancer Center is one of two ongoing Phase I studies with dexanabinol, and the first to evaluate the drug in cancer patients.
“In time, we will explore the association between the molecular phenotype of the tumor and the patient’s response, which may allow us to personalize future therapies,” says Kesari, associate professor, Department of Neurosciences at UC San Diego School of Medicine.
Patients who are eligible for this trial must have failed prior therapy including surgical resection, radiation therapy and systemic therapy.
Article Source can be found here!
Wednesday, September 26, 2012, a public hearing was held in Plattsburgh, New York on the proposed local law #3 of the 2012 “A Local Law to Prohibit the Sale and Possession of Synthetic Cannabinoids and Other Synthetic Drugs Designed, Marketed, or Utilized for Purposes of Simulating the Effect of Illegal Drugs or Controlled Substances.” During the hearing, the only evidence against these “so called” harmful products were short narratives. No facts or evidence were given to prove otherwise yet the vote was unanimous according to some sources, therefore passing this law into the Clinton County Legislature. The penalty some will face for selling these products could be up to one year in jail, and up to three months for possession. However, it will be looked at as a misdemeanor offense because only the state can create harsher punishments. Without the proper education about these products, this type of attitude will continue to spread throughout our nation, and keep allowing the government to overstep their boundaries and squash what little civil liberties we have left.
Synthetic Drug Bust in Newton County
By: KSN, Joplin, MO
Updated: September 19, 2012
NEOSHO, Mo.— Investigators confiscated more than 300 packages of “SYN” from the Music Center on Neosho Boulevard. The product was being sold as incense, costing $10 to $20 a packet. The “SYN” tested positive as a narcotic, making it illegal. It is the fifth warrant issued involving synthetic drugs in Newton County over the last 2 months.
“We want to be known that we are following this and will continue serving search warrants and attempting prosecution on anybody that we find selling it in Newton County. So far, I believe we’ve been pretty successful at getting it out of the area,” says Chris Jennings, Newton County Deputy.
Samples from the product have been sent to a Missouri State Crime Lab. Deputies are waiting for the results before arrests can be made or charges filed.
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The two italicized sentences are obvious contradictions of one another, proving that this journalist should have done more thorough research on his/her topic. Attorney Tim Dandar, herbal incense lawyer, says “this is once again, misinformation at its finest.”
Posted on Tuesday, September 11, 2012 at 6:21 pm
Centralia High School football coach Erle Bennett was one of a number of people who appeared before Centralia aldermen last week to protest the sale of synthetic drugs.
With a unanimous, 6-0 vote, on Sept. 4, the Centralia Board of Aldermen have made it illegal to use, possess or distribute synthetic cannabanoids, imitation marijuana or similar substances within the city limits of Centralia.
According to Attorney Tim Dandar, “The following is just another prime example of unprofessional and unsubstantiated decision making.”
Temporarily amends 856 IAC 2-2-2 to add synthetic compounds to Schedule I. Statutory authority: IC 25-26-13-4.1. Effective 30 days after filing with the Publisher.
SECTION 1. (f) Synthetics. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation, which contains any quantity of the following synthetic substances, or which contains any of its salts, isomers, and salts of isomers, whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation (for purposes of this subsection only, “isomer” includes the optical, position, and geometric isomers):
(1) 5-Methoxy-N,N-Dimethyltryptamine (Some trade names or other names: 5-methoxy-3-[2-(dimethylamino)ethyl]indole; 5-MeO-DMT.)
(2) 2-(2,5-Dimethoxy-4-ethylphenyl)ethanamine (2C-E).
(3) 2-(2,5-Dimethoxy-4-methylphenyl)ethanamine (2C-D).
(4) 2-(4-Chloro-2,5-dimethoxyphenyl)ethanamine (2C-C).
(5) 2-(4-lodo-2,5-dimethoxyphenyl)ethanamine (2C-I).
(6) 2-[4-(Ethylthio)-2,5-dimethoxyphenyl]ethanamine (2C-T-2).
(7) 2-[4-(Isopropylthio)-2,5-dimethoxyphenyl]ethanamine (2C-T4).
(8) 2-(2,5-Dimethoxyphenyl)ethanamine (2C-H).
(9) 2-(2,5-Dimethoxy-4-nitro-phenyl)ethanamine (2C-N).
(10) 2-(2,5-Dimethoxy-4-(n)-propylphenyl)ethanamine (2C-P).
(11) Any compound structurally derived from 3-tetramethylcyclopropanoylindole with substitution at the nitrogen atom of the indol ring by an alkyl, haloalkyl, cyanoalkyl, alkenyl, cycloalkylmethyl, cycloalklethyl, 1-(N-methyl-2-piperidinyl)methyl, 2-(4-morpholinyl)ethyl, 1-(N-methyl-2-pyrrolidinyl)methyl, 1-(N-methyl-3-morpholinyl)methyl, or tetrahydropyranylmethyl group, whether or not substituted in the indole ring to any extent and whether or not substituted in the tetramethylcylopropyl ring to any extent.
(12) UR144 [(1-pentylindol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone].
(13) XLR11 [(1-(5-fluoropentyl)indol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone].
LSA Document #12-493(E)
Composed: Sep 11,2012 5:37:43PM EDT
A PDF version of this document.